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Increased effect of warfarin, lithium, methotrexate, digoxin, cyclosporin, aspirin.

Use with other moat substrates, such as methotrexate, may result in prolonged systemic exposure of the coadministered drug.

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Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aspirin, atenolol tenormin , carteolol cartrol , cyclosporine neoral, sandimmune , diuretics water pills , labetalol normodyne, trandate , lithium eskalith, lithobid , medications for arthritis or diabetes, methotrexate, metoprolol lopressor , nadolol corgard , phenytoin dilantin , probenecid benemid , warfarin coumadin , and vitamins.

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Methotrexate has been used as a steroid sparing agent in subarachnoid disease in patients requiring long-term steroids and experiencing intolerable side effects 99 .

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Otrexup contains methotrexate in a preservative-free sterile solution for a single subcutaneous injection.

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nausea and vomiting are the most common short-term side effects of methotrexate; some kids also feel sleepy, fatigued and generally unwell after taking it.

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